| ncRNA name | HOTAIR |
| ncRNA Category | lncRNA |
| ID | 100124700 |
| Ensembl | ENSG00000228630 |
| Synonyms | HOXC-AS4, HOXC11-AS1, NCRNA00072 |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | RB samples; RB cell lines Y79 and WERI-RB1 |
| Methods | siRNA transfection, qRT-PCR, Western blot, luciferase reporter assay, Subcutaneous xenograft |
| Expression pattern | up-regulated |
| Functional description | Knockdown of HOTAIR restricted the proliferation and invasion of the more invasive retinoblastoma Y79 cells, and led to G0/G1 arrest, possibly through inhibiting phospho-RB1, RB1 and CCNE. Furthermore, we found that the Notch signalling pathway was activated abnormally in retinoblastoma cell lines, while knockdown of HOTAIR attenuated the endogenous Notch signalling pathway in vitro and in vivo. |
| PubMed ID | 27966488 |
| Year | 2016 |
| Title | Long non-coding RNA HOTAIR regulates proliferation and invasion via activating Notch signalling pathway in retinoblastoma. |
| Drug-related ncRNA | NO |
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